Forskningsprosjekter 

Årsrapporter forskningsprosjektene våre:

Årsrapport 2012
Årsrapport 2011
Årsrapport 2010
Årsrapport 2009
Årsrapport 2008
Årsrapport 2007


Doktorgrader:

Kurt Hanevik
Post-giardiasis functional gastrointestinal disorders and chronic fatigue syndrome – clinical symptoms, inflammation and immune responses
Disputert: Januar 2012
Hovedveileder: Nina Langeland
Pressemelding

Bjørn Blomberg
Antimicrobial resistance in bacterial infections in urban and rural Tanzania
Disputert: Mai 2007
Hovedveileder: Nina Langeland
Pressemelding


Publikasjoner:

Nyeste publikasjoner (2011 -)


Giardia-epidemien i Bergen

Mørch K, Hanevik K, Rivenes AC, Bødtker JE, Næss H, Stubhaug B, Wensaas KA, Rortveit G, Eide GE, Hausken T and Langeland N.
Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.
BMC Gastroenterology 2013, 13:28. Epub 2013 febr 06

Hanevik K, Kristoffersen EK, Sørnes S, Mørch K, Næss H, Rivenes AC, Bødtker JE, Hausken T, Langeland N.
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.
BMC Infect Dis 2012 Oct;12(1):258. Epub 2012 okt 14
PMID: 23061432

Hunskar GS, Langeland N, Wensaas KA, Hanevik K, Eide GE, Mørch K, Rortveit G.
The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.
Scand J Gastroenterol 2012 Sep;8-9(47):956-61. Epub 2012 jul 2
PMID: 22746290

Wensaas KA, Langeland N, Hanevik K, Mørch K, Eide GE, Rortveit G.
Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study.
Gut 2012 Feb;61(2):214-9. Epub 2011 sep 12
PMID: 21911849

Hanevik K, Kristoffersen E, Svard S, Bruserud Ø, Ringqvist E, Sørnes S, Langeland N.
Human cellular immune response against Giardia lamblia 5 years after acute giardiasis.
J Infect Dis 2011 Dec;204(11):1779-86. Epub 2011 okt 11
PMID: 21990423

Hanevik K, Dizdar V, Langeland N, Eide G E, Hausken T
Tolerability and effect of mesalazine in postinfectious irritable bowel syndrome.
Aliment Pharmacol Ther 2011 Jul;34(2):259-60.
PMID: 21679211

Robertson LJ, Hanevik K, Escobedo AA, Mørch K, Langeland N.
Giardiasis-why do the symptoms sometimes never stop?
Trends Parasitol 2010 Feb;26(2):75-82. Epub 2010 jan 6
PMID: 20056486

Wensaas KA, Langeland N, Rortveit G.
Post-infectious gastrointestinal symptoms after acute Giardiasis. A 1-year follow-up in general practice.
Fam Pract 2010 Jun;27(3):255-9. Epub 2010 mar 22
PMID: 20308244 

Mellingen KM, Midtun A, Hanevik K, Eide GE, Søbstad Ø, Langeland N.
Post epidemic giardiasis and gastrointestinal symptoms among preschool children in Bergen, Norway. A cross-sectional study.
BMC Public Health 2010;10():163. Epub 2010 mar 26
PMID: 20346102

Escobedo AA, Almirall P, Robertson LJ, Franco RMB, Hanevik K, Mørch K, Cimerman S
Giardiasis: the ever-present threat of a neglected disease.
Infect Disord Drug Targets 2010 Oct;10(5):329-48.
PMID: 20701575

Wensaas KA, Langeland N, Rortveit G.
Prevalence of recurring symptoms after infection with Giardia lamblia in a non-endemic area.
Scand J Prim Health Care 2009;27(1):12-7.
PMID: 19085428
 
Hanevik K, Dizdar V, Langeland N, Hausken T.
Development of functional gastrointestinal disorders after Giardia lamblia infection.
BMC Gastroenterol 2009;9():27. Epub 2009 apr 21
PMID: 19383162

Mørch K, Hanevik K, Rortveit G, Wensaas KA, Eide GE, Hausken T, Langeland N.
Severity of Giardia infection associated with post-infectious fatigue and abdominal symptoms two years after.
BMC Infect Dis 2009;9():206. Epub 2009 des 15
PMID: 20003489

Mørch K, Hanevik K, Robertson LJ, Strand EA, Langeland N.
Treatment-ladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway. 
J Infect. 2008 Apr;56(4):268-73.  

Hanevik K, Mørch K, Eide GE, Langeland N, Hausken T.
Effects of albendazole/metronidazole or tetracycline/folate treatments on persisting symptoms after Giardia infection: a randomized open clinical trial. 
Scand J Infect Dis. 2008;40(6-7):517-22   

Strand EA, Robertson LJ,Hanevik K, Alvsvåg JO,Mørch K, Langeland N.
Sensitivity of a Giardia antigen test in persistent giardiasis following an extensive outbreak. 
Clin Microbiol Infect. 2008 Nov;14(11):1069-71.  

Wensaas KA, Langeland N, Rortveit G.
Prevalence of recurring symptoms after infection with Giardia lamblia in a non-endemic area.
Scand J Prim Health Care. 2008 Dec 12:1-6.  

Mørch K, Hanevik K, Rortveit G, Wensaas KA, Langeland N.
High rate of fatigue and abdominal symptoms two years after an outbreak of giardiasis. 
Transactions of Royal Society of Tropical Medicine and Hygiene (2009) 103, 530-532.

Nygard K, Schimmer B, Sobstad O, Walde A, Tveit I, Langeland N, Hausken T, Aavitsland P.
A large community outbreak of waterborne giardiasis-delayed detection in a non-endemic urban area.
BMC Public Health. 2006 May 25;6:141.

Robertson LJ, Hermansen L, Gjerde BK, Strand E, Alvsvåg JO, Langeland N. 
Application of genotyping during an extensive outbreak of waterborne giardiasis in Bergen, Norway, during autumn and winter 2004.
Appl.Environ.Microbiol. 2006; 72:2212-7.

Robertson LJ, Forberg T, Hermansen L, Gjerde BK, Alvsvåg JO, Langeland N
Cryptosporidium parvum infections in Bergen, Norway, during an extensive outbreak of waterborne giardiasis in autumn and winter 2004.
App Environ Microbiol. 2006;72(3):2218-20

Robertson LJ, Forberg T, Hermansen L, Gjerde BK and Langeland N. 
Molecular characterisation of giardia isolates from clinical infection following a waterborne outbreak.
J Infect. 2007 Jul;55(1):79-88. Epub 2007 Mar 26.

Robertson LJ, Forberg T, Hermansen L,  Gjerde B, Langeland N.  
Demographics of giardia infections in Bergen, Norway, subsequent to a waterborne outbreak. 
Scand J Infect Dis. 2007 Jul 31;:1-4 [Epub ahead of print]

Hanevik K, Hausken T, Morken MH, Strand EA, Mørch K, Coll P, Helgeland L, Langeland N.  
Persisting symptoms and duodenal inflammation related to Giardia duodenalis infections.
Journal of infection. Epub Oct 2007.

Mørch K, Myrvang B.
Treatment of malaria in Norway.
Tidsskr Nor Laegeforen 2012 Mar;132(6):664-7.
PMID: 22456148

Calleri G, Behrens RH, Schmid ML, Gobbi F, Grobusch MP, Castelli F, Gascon J, Bisoffi Z, Jelinek T, Caramello P.
Malaria chemoprophylaxis recommendations for immigrants to Europe, visiting relatives and friends-a Delphi method study.
Malar J 2011;10():137. Epub 2011 mai 20
PMID: 21599909

Zoller T, Junghanss T, Kapaun A, Gjorup I, Richter J, Hugo-Persson M, Mørch K, Foroutan B, Suttorp N, Yürek S, Flick H.
Intravenous artesunate for severe malaria in travelers, Europe.
Emerg Infect Dis 2011 May;17(5):771-7.
PMID: 21529383

Mørch K, Strand Ø, Dunlo OO, Berg A, Langeland N, Leiva RAM, Longva JÅ, Sjursen H, Skrede S, Sundal J, Jensenius M.
Severe malaria and artesunate treatment, Norway.
Emerging Infectious Diseases 2008 Nov;11(14):1816-1818 2.

Berg A, Patel S, Langeland N, Blomberg B.
Falciparum malaria and HIV-1 in hospitalized adults in Maputo, Mozambique: does HIV-infection obscure the malaria diagnosis? 
Malar J. 2008 Dec 15;7(1):252.  

Morch K, Feruglio SL, Ormaasen V, Bruun JN.
[Severe falciparum malaria treated with exchange transfusion]
Tidsskr Nor Laegeforen. 2002 Apr 20;122(10):999-1001

Blomberg B, Jureen R, Manji KP, Tamim BS, Mwakagile DS, Urassa WK, Fataki M, Msangi V, Tellevik MG, Maselle SY, Langeland N.
High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania.
J Clin Microbiol. 2005 Feb;43(2):745-9.

Blomberg B, Mwakagile DS, Urassa WK, Maselle SY, Mashurano M, Digranes A, Harthug S, Langeland N.
Surveillance of antimicrobial resistance at a tertiary hospital in Tanzania.
BMC Public Health. 2004 Oct 11;4:45.

Vaagland H, Blomberg B, Kruger C, Naman N, Jureen R, Langeland N.
Nosocomial outbreak of neonatal Salmonella enterica serotype Enteritidis meningitis in a rural hospital in northern Tanzania.
BMC Infect Dis. 2004 Sep 14;4:35.

Ndugulile F, Jureen R, Harthug S, Urassa W, Langeland N.
Extended spectrum beta-lactamases among Gram-negative bacteria of nosocomial origin from an intensive care unit of a tertiary health facility in Tanzania.
BMC Infect Dis. 2005 Oct 15;5:86.

Blomberg B, Olsen BE, Hinderaker SG, Langeland N, Gasheka P, Jureen R, Kvale G, Midtvedt T.
Antimicrobial resistance in urinary bacterial isolates from pregnant women in rural Tanzania: implications for public health.
Scand J Infect Dis. 2005;37(4):262-8.


Tuberkulose

Dyrhol-Riise AM, Gran G, Wentzel-Larsen T, Blomberg B, Haanshuus CG, Mørkve O.
Diagnosis and follow-up of treatment of latent tuberculosis; the utility of the QuantiFERON-TB Gold In-tube assay in outpatients from a tuberculosis low-endemic country.
BMC Infect Dis 2010;10:57. Epub 2010 mar 8
PMID: 20210999 

Blomberg B, Langeland N.
Tuberculous meningitis and resistance to isoniazid.
BMJ 2010;341():c4677. Epub 2010 sep 6
PMID: 20819876

Storla DG, Kristiansen I, Oftung F, Korsvold GE, Gaupset M, Gran G, Øverby AK, Dyrhol-Riise AM, Bjune GA.
Use of interferon gamma-based assay to diagnose tuberculosis infection in health care workers after short term exposure.
BMC Infect Dis 2009;9:60. Epub 2009 mai 11
PMID: 19432995

Wiker HG, Mustafa T, Malen H, Riise AM.
Vaccine approaches to prevent tuberculosis.
Scand J Immunol. 2006 Sep;64(3):243-50.

Baba K, Sornes S, Hoosen AA, Lekabe J, Mpe J, Langeland N, Dyrhol-Riise AM.
Evaluation of Immune Responses in HIV-infected Patients with Pleural Tuberculosis by the QuantiFERON TB-Gold Interferon-gamma assay. BMC Infect Dis. 2008 Mar 14;8:35

Baba K, Pathak S, Sviland L, Langeland N, Hoosen A, Åsjø B, Dyrhol-Riise AM, Mustafa T.
Real-time quantitative PCR in the diagnosis of tuberculosis in formalin-fixed paraffin-embedded pleural tissue in patients from a high HIV endemic area.
Diagn Mol Pathol. 2008 Jun;17(2):112-7.

Baba K, Dyrhol-Riise A.M, Sviland L, Langeland N, Hoosen, Wiker H.G, Mustafa.
Rapid and specific diagnosis of tuberculous pleuritis with immunohistochemistry by detecting Mycobacterium tuberculosis complex specific antigen MPT64 in patients from a high HIV endemic area.
Appl Immunohistochem Mol Morphol. 2008 Aug 11.

Baba K, Hoosen AA, Langeland N, Dyrhol-Riise AM.
Adenosine deaminase activity is a sensitive marker for the diagnosis of tuberculous pleuritis in patients with very low CD4 counts.
PLoS ONE. 2008 Jul 30;3 (7).

Polio

Rekand T, Strand I, Langeland N, Haarr L. 
[Can poliomyelitis be eradicated in near future?]
Tidsskr Nor Laegeforen. 2005 Sep 22;125(18):2516-7.

Rekand T, Langeland N, Aarli JA, Vedeler CA. 
Fcgamma receptor IIIA polymorphism as a risk factor for acute poliomyelitis.
J Infect Dis. 2002 Dec 15;186(12):1840-3. Epub 2002 Nov 19.

Rekand T, Male R, Myking AO, Nygaard SJ, Aarli JA, Haarr L, Langeland N. 
Detection of viral sequences in archival spinal cords from fatal cases of poliomyelitis in 1951-1952.
J Virol Methods. 2003 Dec;114(1):91-6.

Rekand T, Korv J, Farbu E, Roose M, Gilhus NE, Langeland N, Aarli JA. 
Lifestyle and late effects after poliomyelitis. A risk factor study of two populations.
Acta Neurol Scand. 2004 Feb;109(2):120-5.

Immunologi

Lugada ES, Mermin J, Kaharuza F, Ulvestad E, Were W, Langeland N, Asjo B, Malamba S, Downing R. 
Population-based hematologic and immunologic reference values for a healthy Ugandan population.
Clin Diagn Lab Immunol. 2004 Jan;11(1):29-34

Herpes Simplex

Kasubi MJ, Nilsen A, Marsden HS, Bergstrom T, Langeland N, Haarr L.
Prevalence of antibodies against herpes simplex virus types 1 and 2 in children and young people in an urban region in Tanzania.
J Clin Microbiol. 2006 Aug;44(8):2801-7.

Nilsen A, Mwakagile D, Chalamila G, Langeland N, Matre R, Haarr L.
Demographic and behavioural factors in Tanzanian and Norwegian patients with sexually transmitted infections.
Acta Derm Venereol. 2006;86(4):320-8.

Kasubi MJ, Nilsen A, Marsden HS, Bergstrom T, Langeland N, Haarr L. 
A branched, synthetic oligopeptide corresponding to a region of glycoprotein G of HSV-1 reacts sensitively and specifically with HSV-1 antibodies in an ELISA.
J Virol Methods. 2005 May;125(2):137-43.